Energy Crisis: ATP Deficiency Dooms Motor Neurons in Computer Model

Computer, mouse, and keyboard ALZFORUM

By Amber Dance

For the first time, ALS researchers have used computational modeling to probe why motor neurons are so susceptible to degeneration. They report in the July 31 Neuron online that even a slight dearth of ATP pitches the in silico neurons into a deadly feedback loop, in which sodium-potassium pumps demand more and more energy from an ever-dwindling cellular supply. In a real neuron, this presumably would be fatal, said study co-author Serge Przedborski of Columbia University in New York. [Read more…]

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